Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

• Sergii Afonin,
• Oleg Babii,
• Aline Reuter,
• Volker Middel,
• Masanari Takamiya,
• Uwe Strähle,
• Igor V. Komarov and
• Anne S. Ulrich

Beilstein J. Org. Chem. 2020, 16, 39–49, doi:10.3762/bjoc.16.6

• [51], are excluded from the legislation governing animal testing, i.e., experiments do not require ethical approval. In this study, we selected 19 photoswitchable DAE-modified cytotoxic peptides from our previous SAR evaluation [30] and established with them the D. rerio embryotoxicity assay. For each

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• extremely hemolytic. This work demonstrates a novel approach for the design of unexplored antimicrobial peptide sequences but it also reveals that the biological and cytotoxic activities of these polypeptides depend on a number of interrelated factors. Keywords: antimicrobial peptides; cytotoxic peptides

Antibiotic and cytotoxic peptides

• Norbert Sewald

Beilstein J. Org. Chem. 2012, 8, 1144–1145, doi:10.3762/bjoc.8.127

• Norbert Sewald Bielefeld University, Department of Chemistry, Organic and Bioorganic Chemistry, Universitätsstr. 25, 33615 Bielefeld, Germany 10.3762/bjoc.8.127 Keywords: antibiotic; cytotoxic; peptides; Through evolution, nature has provided practically all organisms with secondary metabolites

• Journal of Organic Chemistry on “Antibiotic and cytotoxic peptides”: The fight against bacterial infections is in a critical phase. The excessive application of antibiotics in human therapy, and also in livestock breeding, leads to the rapid development of highly virulent bacterial strains resistant to

• the conventionally applied antibiotics. Consequently, the search for new antibiotically active compounds is of premier importance. On the other hand, highly cytotoxic peptides and peptide analogues, such as monomethyl auristatin E, are used as the “warhead” in antibody–drug conjugates for tumor